Skip to main content
Maria Cirino headshot

Maria Cirino

Founding Managing Partner, .406 Ventures Fund.406 Ventures FundBoston, MA

Current Firm

.406 Ventures Fund

Investments

1+ companies

Focus

Digital Health, Cybersecurity

About Maria Cirino

Maria Cirino is a serial founder-operator who scaled i-Cube from ~$5M to a $50M run rate through an IPO, then co-founded security company Guardent and sold it to VeriSign for ~$142M, giving her unusually deep credibility with technical founders compared to most VCs. At .406 Ventures, she focuses on enterprise IT, security, infrastructure, and digital health investments, bringing an operational mindset and apprenticeship model to help founders position and sell deeply technical products that are difficult for generalist VCs to underwrite.

Focus Areas

Digital HealthCybersecurityAIEnterprise

Investment Stage

Pre-Seed
Seed
Series A
Series B+

Notable Investments

Liam Donohue