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Lynne Chou O'Keefe headshot

Lynne Chou O'Keefe

Founder and Managing Partner, Define VenturesDefine VenturesSan Francisco, CA

Current Firm

Define Ventures

Investments

10+ companies

Focus

Digital Health, AI

About Lynne Chou O'Keefe

Lynne Chou O'Keefe brings unusual hands-on medical device experience from Guidant and Abbott Vascular to venture capital, having launched over ten product families before becoming a VC, which gives her a deeper understanding of product development, regulation, and commercialization than most digital health investors. She was an early board member at Livongo during its journey from startup to IPO and multibillion-dollar acquisition, and now focuses exclusively on early-stage digital health companies at Define Ventures, positioning herself as a day-zero partner who helps founders shape business models and navigate the complex intersection of consumer experiences and healthcare reimbursement systems.

Focus Areas

Digital HealthAIEnterpriseConsumerSaaS

Investment Stage

Pre-Seed
Seed
Series A
Series B+

Notable Investments

Julian Capital
Harpoon Ventures
Humba Ventures
Fifty Years
Deep Checks
Founders Fund
Lightspeed
Sequoia Capital
Kleiner Perkins
Funds that lead pre-seeds